Gut microbes found in wild wolves may be the key to alleviating a debilitating gastrointestinal condition common to domestic dogs, according to US researchers.
A collaboration between scientists at OSU-Cascades and Oregon State’s Carlson College of Veterinary Medicine report a novel strain of Paenibacillus bacteria with characteristics of a probiotic—an organism that conveys a health benefit to the host.
The team have published their findings in Applied Microbiology.
In this case, the benefit would be to head off canine inflammatory bowel disease, a chronic illness characterised by vomiting, reduced appetite, weight loss, flatulence, a rumbling stomach and/or abdominal discomfort.
“At present there is no known cure for this ongoing dysbiosis of the gastrointestinal tract, and there are limited options for treatment,” Dr Bruce Seal said.
“Underlying causes of the condition include an animal’s genetics, environmental factors, the immunological state of the GI tract and, maybe most importantly, an altered gut microbiome.”
The research is an important step toward a dietary supplement or food additive capable of steering the composition of a dog’s gut microbiome back toward that of the wolf, with which it has common ancestry.
“Dogs were the first domesticated animal,” Dr Seal said.
“The modern dog diet, high in carbohydrates, does not reflect a wolf’s diet—for example, starches in processed dog food are resistant to digestion, and that can have a negative impact on the microbial community in a dog’s GI tract and in turn its gastric physiology.”
In this study, gastrointestinal material was collected from a dead wolf one day after it died from injuries sustained from being struck by a car. The scientists isolated 20 different gut bacteria that preliminary genetic analyses indicate have probiotic qualities, and for this paper they performed whole genome sequencing on a novel Paenibacillus strain.
The bacterium encodes enzymes that can digest complex carbohydrates such as starches. It also has gene systems expressing antimicrobials.
“Non-toxic, spore-forming bacteria promote anti-inflammatory immune responses in the gut and inhibit pathogen growth,” Dr Seal said.
“Taking everything into account, this bacterial isolate could be a potential useful probiotic for domestic dogs.”